Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis

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Spontaneous regression of hepatocellular carcinoma is a rare phenomenon.Abscopal regression of tumours resulting from the effect of irradiation of a tissue on a remote non-irradiated tissue is also rare. The case of a 76 year old Japanese man with hepatocellular carcinoma that regressed after radiotherapy for thoracic vertebral bone metastasis is described. Serum levels of tumour necrosis factor-alpha increased after radiotherapy. The findings suggests that such abscopal related regression may be associated with host immune response, involving cytokines such as tumour necrosis factor-alpha.

(Gut 1998;43:575-577)

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