OC-038 The prevalence of rome iv functional dyspepsia and its impact on health impairment; results from a three-country general population study

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The population prevalence of Rome IV functional dyspepsia and its effect on health impairment is unknown. We used data from a population-based study to address this, and compared somatisation, quality of life, healthcare utilisation, and presence of overlapping irritable syndrome and functional heartburn in individuals fulfilling criteria for Rome IV functional dyspepsia against non-dyspeptic controls.


An internet-based health survey was completed by 6300 general population adults from three English-speaking countries (2100 each from United States, Canada, and United Kingdom). Quota-based sampling was used to ensure equal sex, age, and education distribution across the countries. The survey included questions on demographics, healthcare visits, medication use, criteria for the Rome IV functional dyspepsia as well as for irritable bowel syndrome and functional heartburn, the patient health questionnaire-12 somatisation measure, and the Short Form-8 quality of life questionnaire.


Data was available for analysis from 5931 subjects (49.2% female; mean age 47.4 years, range 18–92). Overall, 551 (9.3%) of the population fulfilled criteria for Rome IV functional dyspepsia. This comprised 339 (61.5%) with postprandial distress syndrome-PDS, 97 (17.6%) with epigastric pain syndrome-EPS, and 115 (20.9%) with both. Subjects with functional dyspepsia had significantly greater health impairment than non-dyspeptic controls, with on average 73% seeking healthcare more than once yearly and 77% taking GI-relevant medication (i.e. GI-specific, psychotropics, analgesia, or complementary medicine). Notably, those with overlapping Rome IV EPS and PDS had higher frequency of co-existing irritable bowel syndrome and functional heartburn, worse somatisation, and poorer mental and physical QOL scores, compared to EPS- or PDS-alone (See table). Somatisation and QOL scores were similar between EPS- and PDS- alone.


Note for table: Mean-values/percentages with different superscript letters are significantly different at a p<0.05 level.


Almost 10% of the population fulfil criteria for Rome IV functional dyspepsia. Subjects with Rome IV functional dyspepsia, in particular those with overlapping PDS and EPS, have considerable health impairment. This is despite frequent healthcare visits and use of GI-relevant medication.

Disclosure of Interest

None Declared

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