PTU-098 Tace for hcc: long term outcome in a regional centre

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Abstract

Introduction

The incidence of hepatocellular carcinoma (HCC) is rising.1,2 Transarterial chemoembolisation (TACE) is frequently used as a palliative treatment or as a bridge to surgery. TACE can be offered alone, or together with radiofrequency ablation (RFA) or Sorafenib. Child-Pugh grade and Barcelona Clinic Liver Cancer Staging System (BCLC) are useful prognostic tools. Our aim was to assess outcome for patients receiving TACE over a 6 year period in our regional centre.

Method

Patients with HCC were prospectively entered onto a regional HCC database between 01.01.09–01.01.15. Patients who underwent TACE (in addition to other therapies) were identified and clinical data obtained from electronic records. Child-Pugh grade and BCLC were calculated at time of diagnosis, with survival our primary outcome.

Results

497 patients were diagnosed with HCC during this period. 121 (99 male, 22 females; mean age 68 years) underwent TACE. 20, 47 and 54 patients had TACE during the periods 2009–10, 2011–12 and 2013–14 respectively. 102 (84%) had TACE alone, 6 (5%) each had TACE with RFA and TACE with Sorafenib, 5 (4%) had TACE then transplant, and two TACE then resection. 87 (72%), 31 (26%) and 3 (2%) had Child-Pugh grade A, B and C disease respectively and 38 (31%), 61 (50%), 20 (17%) and 2 (2%) BCLC stage A, B, C and D.

Results

Of the 102 patients having TACE alone, survival is shown in table:

Results

Two year survival for patients having TACE and RFA was 80%; for TACE and Sorafenib 17% and for TACE then transplant/resection 100%.

Conclusion

There has been a steady rise in the number of patients with HCC undergoing TACE procedures in our unit. Survival following TACE compares favourably to other studies.3,4

Disclosure of Interest

None Declared

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