IDDF2018-ABS-0245 Honey supplementation ameliorates adipocytokines and hepatotoxicity induced by high fat diet on male rats

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Abstract

Background

Nowadays, obesity has become a serious problem worldwide and the cause of many diseases. Honey has been used since the dawn of human civilization contains various ingredients that contribute to its medicinal properties and health-beneficial effects. For this reason, honey could be considered as a potential traditional remedy for various illnesses plaguing mankind. This study was conducted to investigate the protective role of honey supplementation in modulating the hepatic damage and obesity biomarkers associated with obesity on in vivo model.

Methods

Animals were induced obesity by feeding high-fat diet for eight weeks. Then, they were divided into different groups which received normal diet (NC); fed with high-fat diet (HFD) alone or with the treatment of Acacia (HFDAH) or pineapple honey (HFDPH) or orlistat (HFDO). Before and after treatment, the blood samples were collected for assessment of adipocytokines biomarkers (adiponectin, resistin and leptin), lipid profiles (total cholesterol (TC), triglycerides (TG), high and low density lipoprotein (HDL and LDL) and liver function profiles (Alanine aminotransferase (ALT), alkaline phosphatase (ALP) and Aspartate aminotransferase (AST)). Hepatoprotective activity, Hepatosomic Index (HI) and histopathological changes in liver tissues were also evaluated.

Results

Animals administered with honey showed significant (p<0.05) decrease on TC, TG, LDL and significant increase (p<0.05) of HDL when compared to HFD. Interestingly, honey supplementation exhibited a hepatoprotective effects as indicated by reduced ALT and AST levels and HI index. Adipocytokines were markedly ameliorated in HFDPH compared to HFD. Adiponectin levels significantly increased in HFDAH and HFDPH (8.13 and 8.22 ug/mL respectively) compared to HFDO (6.07 ug/mL). Leptin level (p<0.05) decreased from 8.08 to 5.68 ng/mL for the HFDPH compared to HFD. Histopathological changes were observed in the liver tissue of HFD and HFDO treated group. The honey supplementation restored all the biochemical parameters significantly (p<0.05), especially the liver function parameters and histopathological changes when compared to HFD or orlistat.

Conclusions

In conclusion, honey supplementation has positive effects on modulating several biochemical pathways of adipocytokine excretions, lipid profiles as well as hepatoprotective which may potentially be applicable for suppression of obesity and its metabolic complications.

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