In our previous study, we found that Heat Shock transcription Factor 2 (HSF2) was differentially expressed in Ulcerative Colitis (UC) patients and increased in parallel with the severity of UC. So this study is aiming at providing a new noninvasive index for predicting the mucosal healing of UC.Methods
Faecal samples were collected from 51 UC with MES (0,1,2,3) and health controls. The concentration of feacl HSF2 was detected by Elisa. The correlation between faecal HSF2 levels and MES was compared by Pearson correlation analysis. A total of 231 follow-up UC patients were included. The faecal samples were collected in the early morning, and colonoscopy was performed in the next day for MES scoring. MES.Results
The concentration of faecal HSF2 in the normal control group and UC patients with MES=0,1,2,3 were (0.64±0.09, 1.30±0.35, 1.84±0.46,2.38±0.57,3.38±0.42) ng/ml respectively. The level of faecal HSF2 was a positive correlation with MES (r=0.81). The concentration of faecal HSF2 was increasing in the group of UC patients with MES=0,1,2,3 compared with the normal control group. The sensitivity, specificity, positive and negative predictive value of faecal HSF2 to predict mucosal healing was (67.8%,80.9%,67.1% and 81.5%) respectively. The clinical value of specificity and the negative predictive value was better than sensitivity and positive predictive value. The AUC of faecal HSF2 to predict mucosal healing was 0.919 (95% CI:0.846–0.992, p<0.0001).The AUC was greater than 0.9 that indicated the faecal HSF2 had a high accuracy to predict mucosal healing of UC.Conclusions
Faecal HSF2 concentration may be used as a high accuracy noninvasive evaluation index for predicting the mucosal healing of UC.