IDDF2018-ABS-0029 Antioxidant biomarkers in acute pancreatitis

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Abstract

Background

There has been increasing awareness of the role played by oxidative stress in many inflammatory illnesses. In several models, it has been demonstrated that oxygen-derived free radicals are generated during acute pancreatitis (AP). It has been suggested that free radical generation is an important factor in the pathogenesis of AP. There is a convincing body of evidence that antioxidant blood levels diminish during severe AP.

Aims

The study aims to estimate the changes in the serum levels of Total Antioxidant Status(TAS), erythrocyte enzymatic antioxidants: Superoxide Dismutase (SOD) and Glutathion peroxidase (GPx) in AP disease and assess whether TAS is a useful biomarker to prognosis AP patients.

Methods

This study was conducted in General Medicine Department of Thai Nguyen Nation Hospital, in Vietnam. TAS, SOD and GPx were measured in 83 cases of AP and 62 healthy volunteers which were regarded as the control group. Using ELISA kit supplied by Wkea Med Supplies Corp, China.The severity of pancreatitis was scored using Computerised Tomography (CT) severity index, modified severity index and revised Atlanta classification and classified into mild, severe categories.

Results

A significant decrease (p<0.001) in the level of TAS was observed in the study group as compared to that in the control group. A significant decrease (p<0.05) in the level of SOD was observed in the study group as compared to that in the control group. A significant decrease (p<0.05) in the level of GPx was observed in the study group as compared to that in the control group. TAS levels of severe AP patients were statistically lower than mild AP (10.14 U/ml vs 14.06 U/ml, p<0.01).

Conclusions

Reduced antioxidants suggest that oxidative stress plays a vital role in the pathogenesis of AP. The results of this study demonstrated changes in antioxidant biomarker associated with the prognosis AP patients. TAS could be used as a antioxidant biomarker of disease severity.

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