IDDF2018-ABS-0102 Relationship between histological characteristics and braf mutation, P53, KI67 immunoexpression in patients with colorectal polyp in thai nguyen

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Abstract

Background

Changes in immune expression of BRAF, P53, and Ki67 proteins are part of the colorectal carcinogenic mechanisms associated with colorectal polyps.

Aims

To analyse the relationship between histological characteristics and BRAF mutation, P53, Ki67 immunoexpression in patients with a colorectal polyp.

Methods

A total of 81 non-cancerous colorectal polyp patients were randomised to the study. Patients undergoing endoscopic, histopathological and immunohistochemical analyses.

Results

BRAF mutation in the dysplasia area showed an average of 1±0.69, non-dysplasia 0.33±0.49, p=0.001; P53 expression in dysplasia was found to be 1.74±1.38, non-dysplasia 1.22±1.05, p=0.001. Ki67 expression in dysplasia was found to be 1.33±1.18, non-dysplasia 1.20±0.97, p=0.002. The BRAF mutation in dysplasia area detected 50% of the traditional serrated polyps. BRAF mutation in dysplasia had 25% level ++, in pervasive samples, p<0.001. P53 expression in dysplasia was 68.6% level +++in adenoma polyps group, in non-dysplasia area rate 33.3% level +++in non-neoplastic polyp, p<0.001. P53 expression were mainly found in the bottom samples, the dysplasia area was 44.3% level +++, non-dysplasia 15.7% level +++, p=0.02. Ki67 expression in dysplasia area was 35.3% in the level of +++adenoma polyps, non-dysplasia at 20% level +++non neoplastic polyps, p<0.001. Ki67 expression of dysplasia 28.6% level +++was mainly found in the bottom samples, p<0.001.

Conclusions

BRAF mutation is more common in serrated polyps, P53, Ki67 expression are more common in adenomatous polyps. Immunohistochemical changes of these proteins are more common in the dysplasia area and there are differences between cell layers.

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