IDDF2018-ABS-0031 The clinical features of HBSAG and ANTIHBC (+) hepatocellular carcinoma in hepatitis B

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Abstract

Background

Hepatocellular carcinoma (HCC) is the second most common cancer in the Philippines. The most common risk factor for HCC is hepatitis B and C. We investigated the clinical characteristics of HCC with past HBV and correlated it with HBsAg.

Methods

Records of HCC patients with viral hepatitis in aetiology for 7 years were analysed. They were then divided into HBsAg(+)/antiHBC(+) and HBsAg(-)/antiHBC(+). The two groups were compared using T-test and Chi-square for continuous and categorical variables. SPSS version 20 was employed for all analysis.

Results

Among 207 patients, HBsAg +/antiHBc +accounted for 43.48% of the cases, while HBsAg -/antiHBc +56.52%. The average age of presentation was in the 5th to 6th decade of life, with HBsAg (-) being affected at an older age (66.88±11.454; p=0.003). Men were mostly afflicted. HCC from hepatitis C were significantly associated with HBsAg -/antiHBc + (p=0.004). Only INR was statistically significant at p-0.041, with HBsAg (+) having a higher INR at 1.22 vs 1.12 (p=0.041).

Conclusions

The prevalence of antiHBc HCC is common in the Philippines and is more common than HCV related HCC. There are some differences in the clinical characteristics between HBsAg (+) and (-) groups, but this might be due to the first exposure to the virus. It is suggested that the natural course of hepatitis B and the risk for HCC be reconsidered. HCV also contribute to the risk of HCC despite having HBsAg seroclearance.

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