IDDF2018-ABS-0083 Nonalcoholic fatty liver disease is associated with increased atrial fibrillation risk in an elderly chinese population: a cross-sectional study

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Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There is rare research performed among elderly adults.


We conducted this cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease.


We conducted a cross-sectional study of the elderly adults (≥65 years old) who had undergone an annual physical examination at Zhenhai Lianhua Hospital, Ningbo, China in 2014. 1688 participants (930 males and 758 females) with a median age of 72 (68–76) years were included in this analysis. This study excluded the following participants: (1) those with unknown alcohol intake or excessive alcohol intake; (2) those with unknown BMI or BMI2; (3) those with incomplete basic physical data; (4) those with missing liver ultrasonic diagnosis; (5) those with unknown causes of chronic liver disease. This study was approved by the Hospital Ethics Committee. All the participants were verbally informed and agreed to participate in the study. Written informed consent was not required for the observational nature of the study.


We analysed clinical data of the elderly adults (≥65 years) who took health examination in Zhenhai Lianhua hospital, Ningbo, China in 2014.


522 of the 1688 participants were diagnosed with nonalcoholic fatty liver disease, and 39 participants were confirmed as having atrial fibrillation. Nonalcoholic fatty liver disease was associated with risk factors for AF in the elderly Chinese population (OR 1.95, 95% CI 1.03–3.69). Adjustments for age, gender, systolic blood pressure, fasting plasma glucose, γ-glutamyl transpeptidase, high-density lipoprotein, triglycerides, total cholesterol and albumin, nonalcoholic fatty liver disease and prevalent atrial fibrillation remained statistically significant (OR 2.76, 95% CI 1.32–5.77).


Our results show that nonalcoholic fatty liver disease is associated with an increased risk of atrial fibrillation in an elderly Chinese population.

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