Economic evaluation of the impact of nicorandil in angina (IONA) trial

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Abstract

Objective:

To estimate the net cost of adding nicorandil to usual treatment for patients with angina and to compare this with indicators of health benefit.

Design:

Cost effectiveness analysis

Setting:

Based on results of the IONA (impact of nicorandil on angina) trial.

Setting:

Patients: Patients with angina fulfilling the entry criteria for the IONA trial

Setting:

Interventions: In one arm of the trial nicorandil was added to existing antianginal treatment and compared with existing treatment alone.

Main outcome measures:

Costs were for use of hospital resources (for cardiovascular, cerebrovascular, and gastrointestinal reasons), nicorandil, and care after hospital discharge. Benefits were assessed in three ways: (1) IONA trial primary outcome (coronary heart disease (CHD) death, non-fatal myocardial infarction, or hospital admission for cardiac chest pain); (2) acute coronary syndrome (CHD death, non-fatal myocardial infarction, or unstable angina); and (3) event-free survivors at the end of the trial.

Results:

The net cost for each additional IONA trial end point averted was −£5 (−€7). The net cost for each case of acute coronary syndrome averted was −£8 (−€12). The net cost for each event-free survivor was −£5 (−€7). These figures are based on gastrointestinal events that were judged definitely or probably related to nicorandil. When all gastrointestinal events were included these three ratios rose to £567 (€835), £886 (€1305), and £516 (€760), respectively.

Conclusions:

A substantial amount of the additional cost of nicorandil is offset by reduced use of hospital services. The limited comparisons possible with other CHD interventions suggest that nicorandil compares favourably.

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