ASSA14-10-02 Treatment Effect of Trimetazidin on Cardiac Function in Mild-Moderate Systolic Heart Failure Patients with Coronary Heart Disease

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Abstract

Objective

To investigate the treatment effect of trimetazidin in mild-moderate systolic heart failure patients diagnosed with coronary heart disease.

Method

130 patients diagnosed coronary heart disease and systolic heart were consecutive enrolled from December 31th 2012 to December 31th 2013. These patients were randomly divided into routine treatment group who received GDMT (n = 64) and trimetazidin group who received trimetazidin 20 mg tid on the basis of GDMT (n = 66). Pro-BNP, cardiac function (LVEF, LVEDD, E/A ratio) were analysed on admission and 3 months after dismissed.

Results

Improvement on LVEDD were better in trimetazidin group than routine treatment group (p > 0.05),pro-BNP, LVEF, E/A ratio were significantly better in trimetazidin group than routine group (p < 0.05).

Conclusion

Trimetazidin can improve cardiac function in mild-moderate systolic heart failure patients with coronary heart disease.

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