87 Young people with hypertension have cerebral vascular abnormalities that could impair cerebral autoregulation supporting the selfish brain hypothesis

    loading  Checking for direct PDF access through Ovid


BackgroundHigh blood pressure (BP) in childhood is the strongest predictor of hypertension later in life suggesting that the mechanisms responsible are apparent early in life.The selfish brain hypothesis postulates that impaired cerebral auto-regulation in susceptible individuals results in relative hypoperfusion of the brain-stem. The brain responds by activating the sympathetic nervous system to raise BP. Cerebral vascular anomalies such as vertebral artery hypoplasia or incomplete Circle of Willis would make the brain-stem more vulnerable to this hypo-perfusion. It is unclear whether these vascular anomalies are the cause of the hypertension or a consequence of vascular re-modelling due to hypertension.We speculated that if these cerebral vascular anomalies were causative, they should have a high prevalence in young onset hypertensives. Conversely, if these cerebral vascular anomalies were secondary to hypertension, we would expect a low prevalence of cerebral arterial remodelling in a group of people with mild hypertension and a short duration of high BP.MethodsWe undertook a retrospective analysis of all patients under the age of 40 years referred to our Hypertension Clinic between November 2011 and June 2016. As recommended by NICE, we looked for secondary causes and evidence of end organ damage in this population. Our routine protocol for young onset hypertension is to perform biochemical and anatomic screening (using MRI) for secondary causes of hypertension. We collected MRI data on cerebral vascular anomalies in addition to imaging the heart, aorta, adrenals and kidneys.Results65 patients, mean age 30 years (42M, 23F) were included. Mean clinic BP was 147/90 mmHg. 62 underwent comprehensive MRI scanning. A clear anatomical cause for the hypertension was found in 2 people (1 coarctation and 1 hypoplastic kidney). LVH was seen in 15 (24%).Interestingly, cerebral artery anatomical variants (vertebral artery hypoplasia and/or incomplete Circle of Willis) were detected in 26 people (42%).Discussion/ImplicationsCerebral vascular anomalies were common in this population of young people with mild hypertension and only a short duration of high blood pressure. This supports the concept that brain-stem hypo-perfusion might have a pathophysiological role in the aetiology hypertension. This would have important consequences highlighting the need to investigate possible causes of cerebral vascular anomalies in utero or during childhood. Longitudinal studies will help establish whether this causative role is plausible.The selfish brain hypothesis also suggests that a low target BP may not be appropriate in some people where the initial cause of the hypertension is sympathetic activation due to brain-stem hypo-perfusion. It might explain the ”foggy brain” that many hypertensive patients describe when their BP drops after medication.

    loading  Loading Related Articles