Structural architecture supports functional organization in the human aging brain at a regionwise and network level

    loading  Checking for direct PDF access through Ovid


Functional interactions in the brain are constrained by the underlying anatomical architecture, and structural and functional networks share network features such as modularity. Accordingly, age-related changes of structural connectivity (SC) may be paralleled by changes in functional connectivity (FC). We provide a detailed qualitative and quantitative characterization of the SC–FC coupling in human aging as inferred from resting-state blood oxygen-level dependent functional magnetic resonance imaging and diffusion-weighted imaging in a sample of 47 adults with an age range of 18–82. We revealed that SC and FC decrease with age across most parts of the brain and there is a distinct age-dependency of regionwise SC–FC coupling and network-level SC–FC relations. A specific pattern of SC–FC coupling predicts age more reliably than does regionwise SC or FC alone (r = 0.73, 95% CI = [0.7093, 0.8522]). Hence, our data propose that regionwise SC–FC coupling can be used to characterize brain changes in aging. Hum Brain Mapp 37:2645–2661, 2016. © 2016 Wiley Periodicals, Inc.

Related Topics

    loading  Loading Related Articles