Prognostic impact of different TNM-based stage groupings for oral squamous cell carcinoma

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BackgroundThe purpose of this study was to evaluate the prognostic significance of different TNM-based stage groupings proposed in the literature.MethodsWe conducted a retrospective analysis of 300 patients with primary oral squamous cell carcinoma (T1–4, N0–2, M0). The stage grouping systems of the sixth edition of the Union Internationale Contre le Cancer (UICC), T and N Integer Score (TANIS), the Snyderman scheme, the Hart scheme, and the Berg scheme were tested for their prognostic significance. Disease free survival (DFS) was plotted by Kaplan–Meier analysis. Prognostic factors were identified through univariate and multivariate analysis.ResultsOn univariate analysis, all systems revealed discriminatory power for DFS; however, on multivariate analysis, only the Hart scheme predicted DFS. The TANIS did not have a better prognostic ability than the UICC stage grouping.ConclusionUnlike in previous studies, the UICC stage grouping did perform worse than other TNM-based stage groupings, which may be due to the alterations made in the sixth edition. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

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