The prognostic significance of troponin elevation in patients with sepsis: A meta-analysis

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Abstract

Objective

To confirm the association between troponin elevation in patients with sepsis and mortality.

Background

Cardiac troponins are sensitive and specific biomarkers of myocardial injury; however their prognostic significance in patients with sepsis is still debated.

Methods

PubMed and Ovid MEDLINE were searched for original articles using MeSH terms ‘Troponin’ and ‘Sepsis.’ Studies reporting on mortality in patients with sepsis, severe sepsis or septic shock who had troponin measured were eligible for inclusion. Meta-analysis was conducted with Review Manager.

Results

Seventeen studies, with total sample size of 1857 patients were included. Elevated troponin was found to be significantly associated with mortality (Risk ratio: 1.91; 95% CI: 1.65–2.22; p < 0.05).

Conclusions

Troponin elevation in patients with sepsis confers poorer prognosis and is a predictor of mortality. Further studies are needed to see if more aggressive treatment of this subset of patients, or utilizing new therapeutic approaches will improve mortality.

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