Sex differences in leptin modulate ventilation in heart failure

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Leptin modulates ventilation and circulating levels are higher in normal women than men.

Objectives

The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration.

Methods

Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration.

Results

Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = −0.35; F = 5.6; p = 0.02).

Conclusion

Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.

Related Topics

    loading  Loading Related Articles