Although many studies have focused on risk factors for 30-day readmission after coronary artery bypass graft (CABG) surgery, there is very little known about the prevention of modifiable risk factors associated with readmission. The research questions that guided this focused literature review were (1) What are the modifiable risk factors of 30-day readmission after CABG surgery identified in recent literature? and (2) What are the clinical programs and strategies available in preventing 30-day readmission after CABG surgery? A focused literature review from 1997 to 2014 yielded 17 published reports. Findings of this review revealed a significant gap between addressing modifiable patient-specific risk factors and the current clinical program initiatives, which are focused on care processes. Clinical programs and strategies for 30-day readmission after CABG surgery are evolving. Many programs and studies have included discharge planning and education as interventions to prevent 30-day readmissions; however, there is inconsistency in the literature on the impact of early discharge on readmission. Future studies need to focus on targeting the clinical modifiable risk factors and discharge planning and education, which may help to prevent 30-day readmissions.