Desmodium elegansis a medicinal plant commonly used for the treatment of jaundice, fever, paralysis, oedema, asthma, colds, constipation, cough, convulsion, cholecystolithiasis and urolithiasis. The present investigation commenced with various phytochemical screenings and biological studies were carried out on the bark ofDesmodium elegans. Preliminary phytochemical test of the crude extract and various fractions revealed the presence of steroids, saponins, tannins, reducing sugars, cardiac glycosides and caumarines. The antimicrobial activity and phytotoxicity activities of crude extract and various fractions ofDesmodium eleganswere investigated. Significant phytotoxic activity was observed at a higher concentration.