Changing Remedies

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During long-term case management, we can run into situations when the seemingly indicated remedy, which has helped for a long period of time, stops working. Do we have other options, besides looking for a nosode, to select a new remedy? Are there any connections between the different remedies a person requires in his/her lifetime other than the relationships discovered by the old masters of homeopathy like ‘complementary’ or ‘follows well’?

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