Dabigatran: Will It Replace Warfarin for Stroke Prevention in Atrial Fibrillation?

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Dabigatran, a direct thrombin inhibitor, is the first oral alternative to warfarin for stroke prevention in atrial fibrillation. Dabigatran offers several potential advantages over warfarin including ease of dosing, fewer drug interactions, and the lack of required coagulation monitoring. However, its overall effectiveness and safety will depend upon appropriate patient selection. This article discusses factors that should be taken into account when considering dabigatran for patients with atrial fibrillation.

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