Hormonal Regulation of Lipid Metabolism in Healthy Subjects with or without Obesity

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Parameters of insulin resistance and lipid transport were studied in nonobese subjects and in obese subjects with different body fat distribution, and the results were compared with current concepts of the physiological and biochemical mechanisms of abdominal (android) and gluteofemoral (gynoid) types of obesity, concomitant dyslipoproteinemias, and the roles of insulin and insulin resistance in these conditions. Disturbances of the hormonal regulation of lipid metabolism, which manifest themselves as hyperinsulinemia, insulin resistance, and a decreased serum level of the insulin antagonist somatotropin, were associated only with abdominal obesity and were considered to be one of the main causes of atherogenic dyslipoproteinemia in this type of obesity.

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