Down Syndrome Research Group, Medical and Molecular Genetics Center, IRO, Hospital Duran i Reynals, Gran Via s/n, Km 2.7, 08907-L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain1Department of Physiology and Pharmacology, University of Cantabria, 39011-Santander, Cantabria, Spain2Cancer Prevention and Control Unit, ICO, Hospital Duran i Reynals, Gran Via s/n, Km 2.7, 08907-L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain