1Biostatistics and Informatics Laboratory, Genome Institute, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumtani, Thailand;2Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;3Division of Molecular Genetics, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;4Department of Pathology, Faculty of Medicine, Ramathibodhi Hospital, Mahidol University, Bangkok, Thailand;5Department of Medical Sciences, Ministry of Public Health, Center for International Cooperation, Foreign Affairs Section, Nontaburi, Thailand;6Department of Microbiology, Faculty of Science Mahidol University, Bangkok, Thailand;7Department of Information and Computer Technology, Sirindhorn International Institute of Technology (SIIT), Pathumtani, Thailand.
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Communicated by Alastair F. BrownWith the completion of the human genome project, novel sequencing and genotyping technologies had been utilized to detect mutations. Such mutations have continually been produced at exponential rate by researchers in various communities. Based on the population's mutation spectra, occurrences of Mendelian diseases are different across ethnic groups. A proportion of Mendelian diseases can be observed in some countries at higher rates than others. Recognizing the importance of mutation effects in Thailand, we established a National and Ethnic Mutation Database (NEMDB) for Thai people. This database, named Thailand Mutation and Variation database (ThaiMUT), offers a web-based access to genetic mutation and variation information in Thai population. This NEMDB initiative is an important informatics tool for both research and clinical purposes to retrieve and deposit human variation data. The mutation data cataloged in ThaiMUT database were derived from journal articles available in PubMed and local publications. In addition to collected mutation data, ThaiMUT also records genetic polymorphisms located in drug related genes. ThaiMUT could then provide useful information for clinical mutation screening services for Mendelian diseases and pharmacogenomic researches. ThaiMUT can be publicly accessed fromhttp://gi.biotec.or.th/thaimut.