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To evaluate the morphofunctional development of adolescents as dependent on their physiological and chronological ages, physical development, cardiorespiratory system indices, and exercise performance were studied in 12- to 14-year-old boys. The morphofunctional development depended mostly on the sexual maturity. In subjects of the same chronological age, the maturity level substantially influenced the rate of physical development and the condition of the cardiorespiratory system. The maturity stage-dependent increase in absolute morphological and functional indices in 14-year-old adolescents was greater than the age-related increase observed in adolescents with the same stage of sexual maturation.