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Long-term studies related to comprehensive analysis of psychophysiological correlates of the athletic potential were performed on the basis of innovative technologies of molecular genetic and biological energy analyses using modern automated software-hardware complexes. The results were used to select indices for personalized diagnosis of the athletic potential, to analyze it comparatively at the team level, and to calculate an athletic rating correlating with athletic success. These indices make it possible to detect preclinical health disturbances, development of energy deficit, and overtraining. The approaches may be used to analyze the general well-being of a population.