Seminal plasma S-adenosylmethionine and S-adenosylhomocysteine associations in infertile men

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To assess seminal plasma S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) association in infertile men.

Materials and methods

In all, 95 infertile men were investigated and classified in terms of diagnosis into asthenozoospermia, athenoteratozoospermia and oligoathenoteratozoospermia compared with 22 healthy fertile controls. They were subjected to semen analysis, assessment of seminal SAM, SAH, malondialdehyde (MDA), acrosin activity, α-glucosidase, and sperm DNA fragmentation.


In healthy fertile men, seminal SAM, SAM/SAH ratio, α-glucosidase, and acrosin activity were significantly increased, whereas seminal SAH, MDA, and sperm DNA fragmentation percentage were significantly decreased compared with other investigated infertile groups. Seminal SAM and SAM/SAH ratio showed a significant positive correlation with semen parameters, acrosin activity, and α-glucosidase and a significant negative correlation with seminal MDA.


Alteration in the seminal transmethylation pathway in infertile men is associated with increased oxidative stress, sperm DNA fragmentation and decreased sperm acrosin activity, seminal α-glucosidase.

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