Assessment of the effect of unilateral and bilateral prostaglandin E1 intracavernosal injection on cavernosal peak systolic velocity

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Purpose of the study

Comparison of peak systolic velocity after unilateral and bilateral intracavernosal injection of prostaglandin E1 in patients with erectile dysfunction.


One hundred and twenty patients complaining of erectile dysfunction were divided according to penile color doppler ultrasound into three groups (psychogenic, arteriogenic and venogenic) after intracavernosal injection of 20 micrograms PGE1 in one side. Penile color Doppler was repeated by injecting half of the dose of PGE1 on each side. Maximum peak systolic velocity was measured on both sides and compared for each group.


The results showed significant increase of peak systolic velocity on the side of injection after unilateral intracavernosal injection in cases of psychogenic (Right PSV=40.5±4.3 vs. Left PSV=30.8±3.9, P=0.003) and venogenic (Right PSV=41.93±8.34 vs. left PSV=34.10±9.86, P=0.01) erectile dysfunction. On the other hand, no significant difference (P>0.05) was documented in arteriogenic cases following unilateral and bilateral injection, (Right PSV=18.4±4.3 vs. Left PSV=19.8±3.7) and (Right PSV=18.1±4.7 vs. Left PSV=18.7±3.8) respectively.


Dividing the total dose of the vasodilating agent and injecting half of the dose into each corpus cavernosum separately prevents artifactual difference of peak systolic velocity on the right and left sides in psychogenic and venogenic erectile dysfunction, such an effect that could not be demonstrated in arteriogenic cases.

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