Ovarian response to stimulation of HIV-positive patients during IVF treatment: a matched, controlled study

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Abstract

BACKGROUND

Our aim was to compare the ovarian response of HIV-positive and -negative patients during IVF.

METHODS

Setting – HIV and IVF reference university hospital. Twenty-seven HIV-infected patients who had undergone IVF between March 2000 and March 2005 were matched with 77 HIV-negative patients for age, aetiology of infertility, whether it was primary or secondary infertility, duration of infertility, history of pelvic surgery and type of pituitary inhibition. Outcome – poor responders were defined using one of the following criteria: a cancelled cycle (for insufficient ovarian response), less than four mature follicles (≥16 mm), peak serum levels of E2 lower than 1000 pg/ml.

RESULTS

There were no differences between the two groups of patients for the matched criteria. The proportion of African women and of women with a history of pelvic inflammatory disease was significantly higher among HIV patients than among the control group. With the exception of a lower number of transferred embryos among HIV-positive patients versus HIV-negative ones (1.3 versus 1.9; P=0.035), there was no significant difference between the two groups of patients regarding ovarian response parameters.

CONCLUSION

HIV-infected patients who are in good general condition and who are matched to a control group present a similar ovarian response to stimulation, suggesting the existence of a similar ovarian reserve.

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