Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri

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Abstract

BACKGROUND

Prostaglandins (PGs) are important stimulators of uterine contractility. Limited data are available at present on the effects of different PGs on uterine contractility, measured using intraluminal pressure changes in the complete uterus. The goal of this study was to assess dynamic changes in uterine contractility and peristalsis in response to PGs in comparison with the effects of oxytocin administration.

METHODS

An extracorporeal perfusion model of swine uteri was used, which keeps the uterus in a functional condition, and is appropriate for the study of physiological questions. Oxytocin- and PG-induced uterine contractility and peristalsis were assessed using an intrauterine double-chip microcatheter.

RESULTS

A dose-dependent increase in intrauterine pressure (IUP) in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was observed after the administration of PGF2α and oxytocin, which reached a plateau after further stimulation. A dose-dependent increase in IUP in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was also observed after the administration of PGE1 and PGE2, with a plateau in IUP in the middle-concentration range and a decrease in the course of further stimulation. PGE2 caused significantly more contractions starting in the corpus uteri and moving to the isthmus uteri (P=0.008). The direction of most contractions caused by PGE1, PGE2 and oxytocin differed from that of PGF2α.

CONCLUSIONS

This study demonstrates that the PGs tested modulate contractility in non-pregnant swine uteri in a characteristic way, resulting in different contractility patterns.

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