The objective was to compare the efficacy of oral versus vaginal misoprostol for cervical ripening in non-pregnant women.METHODS
Sixty non-pregnant women scheduled for diagnostic hysteroscopy were randomized by computerized randomization schedule to 400 µg of misoprostol orally (n=30) or 200 µg vaginally (n=30) administered 12 h prior to surgery. The diameter of the cervical canal measured with a Hegar dilator, adverse events and any complications were recorded and compared between the two groups.RESULTS
The mean pre- and post-medication cervical canal diameter and cervical diameter difference were 2.00 ± 1.93 versus 2.37 ± 1.83 mm (P=0.453), 5.10 ± 1.75 versus 5.60 ± 1.69 mm (P=0.265) and 3.10 ± 1.79 versus 3.23 ± 1.74 mm (P=0.771) in the oral and vaginal group, respectively. Seven patients in the oral group and one patient in the vaginal group experienced diarrhoea within 24 h of administration of the misoprostol.CONCLUSION
Oral misoprostol 400 µg had similar efficacy in cervical ripening to 200 µg of vaginal misoprostol.