Abstract 223: Relationship Between Leukocyte Count and Platelet Count as Markers of Inflammation and Obesity in Patients With Acute Chest Pain

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Introduction Obesity is associated with low-grade chronic inflammation which has been linked to complications of obesity including coronary artery disease. Epicardial adipose tissue volume (EATv), a surrogate of visceral adiposity burden, has been reported to be associated with adverse cardiovascular risk factor profiles. The aim of this study was to examine the relationship between leukocytes count and platelet count as markers of inflammation and obesity defined by body mass index (BMI) and EATv in patients with acute chest pain.

Methods In this cross-sectional study, 1030 consecutive patients without reported history of coronary artery disease who presented with acute chest pain to our hospital were included. Patients with any signs of infection or inflammation were excluded. Cardiac risk, complete blood counts and EATv measured by non-contrast multi-detector computed tomography scan were collected. Patients were categorized by BMI classification and EATv quartiles. Data were described in mean and standard deviation. Students’t-test, ANOVA and linear regression analysis were used when appropriate.

Results The population consisted of 21.2% (206 of 972) patients without overweight or obesity, 33.2% (323 of 972) with overweight, 45.6% (443 of 972). A subset of 72% (704 of 972) has EATv measured. Compared to non-overweight/non-obese group, obese group have similar leukocyte count (mean 7800±3330 vs 8200±7600; p-value=0.349) and platelet count (mean 253.07±71.51vs 240.96±79.25; p-value=0.056) but higher absolute lymphocyte count (mean 2180±1620 vs 1940±1840; p=0.04). Obese group also had higher absolute lymphocyte count compared to overweight group (2180±1620 vs 1940±1030; p=0.003). BMI is independently associated with absolute lymphocyte count in linear regression analysis (beta = 17). Among EATv quartiles, there was no significant difference in leukocytes count, absolute neutrophil count, absolute lymphocyte count and platelet count.

Conclusion Neither leukocyte count nor platelet count is correlated with obesity defined by either BMI or epicardial adipose tissue volume. However, higher BMI is independently associated with higher absolute lymphocyte count in patients with acute chest pain.

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