Renal Blood Flow and Glomerular Filtration Rate in Renal Wrap Hypertension in Rabbits


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Abstract

Serial measurements of mean arterial pressure and glomerular filtration rate (GFR) were made in rabbits before and 10, 28 and 56 days after bilateral renal cellophane wrap (n=8) or sham operation (n=6). No significant changes were seen 10 days after renal wrap, but by 28 days GFR was reduced by 50 ± 3% and mean arterial pressure had risen by 42 ± 5 mmHg. No significant further changes occurred over the subsequent month. Changes in plasma renin activity after renal wrapping were not significantly different to those seen after sham operation.In a separate series of experiments, renal extraction ratio of para-aminohippurate (PAH), 28 days after renal wrap, averaged 63 ± 4% (n=6) compared to 83 ± 2% (n=5) after sham operation. Calculated renal blood flow of the hypertensive rabbits was only about 40% of that in the sham operated rabbits.Thus large reductions in GFR, renal blood flow and PAH extraction ratio occurred following bilateral renal wrapping and these changes may reflect compression of the kidney by the cellophane induced fibrous capsule. These reductions occurred concomitantly with the rise in arterial blood pressure.

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