Effect of Ganglionic Blockade with Trimethaphan on Corticosteroid Responses to Metoclopramide in Rhesus Monkeys


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Abstract

In order to investigate whether metoclopramide stimulates 18-hydroxycorticosterone and aldosterone production directly by way of the autonomic nervous system, we have examined the effects of ganglionic blockade with trimethaphan on the responses to metoclopramide (200 μg/kg) in rhesus monkeys. Trimethaphan, infused at a rate (200 μg/kg/min) which significantly decreased mean arterial pressure from 122 ± 7 to 62 ± 4 mmHg, did not alter the peak plasma 18-OHB and aldosterone responses to metoclopramide. These results suggest that 18-hydroxycorticosterone and aldosterone responses to metoclopramide occur independently of adrenergic neuronal input.Journal of Hypertension 2:367-370, 1984

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