A Novel Principle for Detection of Systolic and Diastolic Blood Pressure Tested in Man and Rat with Special Reference to its Applicability in Rat Studies


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Abstract

A non-invasive procedure for the application of a photodetector method in rat studies to obtain both systolic and diastolic blood pressure measurements is described. The method has been tested against well-established procedures in rats and in human beings and has proved sufficiently fast and reliable for use in long-term studies. Regression analysis of simultaneously obtained invasive versus non-invasive measurements yielded correlation coefficients of 0.99 and 0.98 respectively. Comparison with the Korotkoff principle in human beings yielded correlation coefficients of 0.96 and 0.78 respectively.Journal of Hypertension 2:343-347, 1984

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