Unchanged Pressor Effect of Norepinephrine in Normal Man Following the Oral Administration of Two Angiotensin Converting Enzyme Inhibitors, Captopril and HOE 498

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The norepinephrine- (50, 100 and 200 ng/kg per min) induced rise in blood pressure (BP) was determined in six healthy male volunteers following angiotensin converting enzyme (ACE) inhibition by either captopril (100 mg orally) or HOE 498 (10 mg orally). In terms of absolute BP measurements both compounds induced a reduction in basal and norepinephrine stimulated BP, whereas norepinephrine induced increments of BP above individual basal levels were unchanged by either converting enzyme inhibitor. It is concluded that attenuation of the pressor response to norepinephrine does not contribute to the hypotensive action of ACE inhibitors in healthy man.

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