The roles of angiotensin II and prostaglandins in the regulation of the glomerular filtration of albumin


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Abstract

Angiotensin (Ang) II and prostaglandins, especially prostaglandins E2 and l2, regulate the glomerular filtration of albumin. Albuminuria can be induced by angiotensin II and possibly by prostaglandins. Angiotensin converting enzyme inhibiton with captopril, enalapril or lisinopril reduces albuminuria and glomerular injury in experimental and clinical renal diseases, especially diabetes mellitus. Inhibition of prostaglandin synthesis with non-steroidal anti-inflammatory drugs reduces albuminuria in nephrotic patients regardless of the aetiology of the nephrosis. Judicious clinical use of either class of therapy can result in sustained reductions (50—75%) in proteinuria and possible attenuation of the rate of decline of glomerular function

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