Reduction of L i +-Na+ countertransport by physiological levels of insulin in vitro

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We studied the effect of insulin at concentrations of 0 to 50 mU/l and glucose at 0 to 20mmol/l on Li+-Na+ countertransport in erythrocytes from normotensive human subjects. While insulin produced a dose-dependent decrease in the rate of Li+-Na+ countertransport, from 0.272 mmol/l erythrocytes per h at zero insulin to 0.081 at a concentration of 50 mU/l (P<0.0001), alterations in ambient glucose concentration had no significant effect on the rate of countertransport. Physiological levels of insulin appear to reduce Li+-Na+ countertransport in vitro by a mechanism which is not related to glucose concentration or transport.

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