A comparison of the effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on the structural changes associated with hypertension in rat small arteries


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Abstract

Objective:To investigate whether, when angiotensin converting enzyme inhibitors are administered to young, genetically hypertension-prone animals, the demonstrated attenuation of blood pressure development and prevention of the structural changes usually observed in small arteries is attributable to the prevention of angiotensin II production.Design:We have treated spontaneously hypertensive rats (SHR) aged 4-20 weeks with either lisinopril (1 or 10mg/kg) or the angiotensin II receptor antagonist D8731 (1, 20 or 50 mg/kg).Methods:Blood pressure was measured and structural parameters in small arteries from four vascular beds were examined using isometric myography.Results:At age 20 weeks lisinopril had attenuated blood pressure development and prevented cardiac hypertrophy (but not vascular hypertrophy) in a dose-dependent manner. The highest dose of lisinopril had reduced the blood pressure of the SHR to below that of the Wistar-Kyoto (WKY) rats and prevented most structural changes, but there was a slight reduction in body weight in those rats. Comparable blood pressure control with D8731 was associated with similar structural parameters.Conclusion:The prevention of hypertension-associated vascular structural alteration appears to be dependent upon the degree of blood pressure control.

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