P-042 Clinical Characteristics and Long-term Outcomes of Elderly-Onset Ulcerative Colitis

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With the aging of the population, the incidence of elderly-onset ulcerative colitis (EOUC) is expected to increase. The aim of this study was to investigate clinical characteristics and outcomes of patients with EOUC.


We retrospectively analyzed 3062 Korean UC patients who were diagnosed between 1977 and 2016 and managed at Asan Medical Center, Seoul, Korea. Characteristics and outcomes of EOUC patients, defined as age ≥60 years at diagnosis of UC, were compared with those of nonelderly-onset UC (NEOUC) patients.


Out of 3062 patients, 226 EOUC patients (7.4%, median age at diagnosis 66.0 [IQR, 60.0–90.5], male 58.4%) were identified. The frequency of EOUC increased from 3.9% between 1977 and 1999 to 9.7% between 2008 and 2014 (P < 0.001). There were more ex-smokers in the EOUC group (P < 0.001). In the EOUC group, extensive colitis at diagnosis of UC and extensive colitis as maximum extent was less common than in the NEOUC group (13.7% versus 22.6%, P = 0.002, and 34.5% versus 42.5%, P = 0.024, respectively). During follow-up (median 93.5 mo [IQR, 12.1–449.0]), the proportions of patients who were ever treated with corticosteroids and anti-TNF agents were similar, but, the use of thiopurine was less frequent in EOUC group (17.8% versus 24.6%, P = 0.023). Cumulative probabilities of colectomy at 5, 10 and 20 years after UC diagnosis were 7.4%, 7.9% and 9.0%, respectively in the EOUC group, and 2.8%, 4.8% and 7.3%, respectively in NEOUC group (P < 0.001).


The frequency of EOUC appears to be increasing in recent years. EOUC group is likely to show distinct features at diagnosis and during follow-up compared with NEOUC group. More attention and further studies are needed in this special group of patients.

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