P-101 Younger Ulcerative Colitis Patients with Earlier Disease Onset More Often Might Have Gut Colonisation with ESBL Producing Enterobacteriaceae

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Abstract

Background:

Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae are the most frequently found multi-drug resistant bacteria colonizing the gut of ulcerative colitis (UC) patients in 4% to 11% of the cases. The objective of this study was to determine the potential differences in gender, age and disease onset between UC patients with and without ESBL producing Enterobacteriaceae colonizing their gut.

Methods:

All consecutive patients with clinically, endoscopically and histopathologically confirmed UC hospitalized in tertiary care hospital in Riga, Latvia during 2012 to 2015 were selected and included in the study. Demographic and disease history data were collected during the interviews. Rectal swabs were collected, Enterobacteriaceae were isolated and tested for ESBL presence according to EUCAST guidelines.

Results:

Sixty-five patients with confirmed UC diagnosis were included in the study. In 7 (10.8%) UC cases patient's gut was colonized with ESBL producing Enterobacteriaceae. Thirty-six (55.4%) of the UC patients were male and 29 (44.6%) were female with the mean age of 45.17 ± 15.44 years. Patients whose gut was colonized with ESBL producing Enterobacteriaceae were more than 10 years younger (35.43 ± 18.57) than patients whose gut was not colonized with ESBL producing Enterobacteriaceae (46.34 ± 14.78) (P = 0.034). The mean age of onset in UC patients with gut colonization with ESBL producing Enterobacteriaceae was 32.14 ± 19.17, whereas in patients without gut colonization with ESBL producing Enterobacteriaceae was 39.60 ± 12.82 (P = 0.05).

Conclusions:

Gut colonization with ESBL producing Enterobacteriaceae more often was found in younger ulcerative colitis patients and patients with earlier disease onset. Further studies should be conducted to analyze the possible ESBL acquisition risk factors in younger patients with earlier diseases onset opposed to older ones with later disease onset.

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