P-104 Association Between pANCA Status and Clinical Characteristics and Outcomes of Ulcerative Colitis: A Meta-analysis

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Abstract

Background:

There are conflicting results on the relationship between perinuclear anti-neutrophil cytoplasmic antibody (pANCA) status and clinical features of ulcerative colitis (UC). The aim of this study was to evaluate whether pANCA status is associated with the phenotypes and the clinical outcomes in UC.

Methods:

A systematic literature search of PubMed, EMBASE, and Cochrane Library was conducted to identify studies that investigated the phenotypes and clinical outcomes among patients with UC based on pANCA status. Clinical characteristics including gender, extraintestinal involvements, and disease extent and various clinical outcomes including steroid or immunomodulator use, and colectomy rate were measured. If significant heterogeneity was present, a random-effects model was used for data pooling.

Results:

Eleven studies with a total of 2166 patients with UC were included. The meta-analysis showed significant lower prevalence of pANCA-positive status in male gender (odds ratio [OR] 0.61, 95% confidence interval [CI], 0.48–0.77). Moreover, pANCA-positive status was associated with pancolonic involvement of UC (OR 1.23, 95% CI, 1.01–1.51). On the other hands, pANCA-positive status was not associated with extraintestinal involvement (OR 0.87, 95% CI, 0.48–1.58), corticosteroid use (OR 1.40, 95% CI, 0.95–2.07), immunomodulator use (OR 1.38, 95% CI, 0.82–2.32), and colectomy (OR 1.11, 95% CI, 0.72–1.73).

Conclusions:

This meta-analysis revealed that positive pANCA status is significantly higher in female patients, and associated with pancolonic involvement of UC.

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