Despite many studies exist about anemia in Crohn's Disease (CD), information about iron-deficiency without anemia (IDWA) is still scarce. The aim of this study was to characterize CD patients who had IDWA, as well as their evolution during the follow-up.Methods:
CD patients who had at least one episode of IDWA between January of 2011 and December of 2014 were included in our study. Iron-deficiency was defined as serum ferritin <30 μg/L in the absence of inflammation or serum ferritin between 30 and 100 μg/L when inflammation was present. Besides characterization of patients' evolution during the follow-up, demographic and clinical differences between the 2 groups were also evaluated using the χ2 and the Fisher's Exact tests.Results:
From the 136 patients with IDWA, 97 (71.3%) were women and the mean follow-up duration was 42 ± 16 months. Regarding the evolution, 43 patients (31.6%) developed anemia, 51 (37.5%) had recovery of the IDWA during the follow-up, 35 (25.7%) had persistent IDWA, and in 7 patients (5.2%) recurrence of IDWA was observed after an initial recovery. Only 8 patients (5.9%) received iron supplements for IDWA. There were no differences between the group with serum ferritin <30 μg/L and the group with serum ferritin between 30 and 100 μg/L concerning gender (P = 0.849), extension (P = 0.91) or behavior of disease (P = 0.056), age at the diagnosis (P = 0.401), perianal (P = 0.571) or upper gastrointestinal tract involvement (P = 0.749), family history of inflammatory bowel disease (P = 0.051) or smoking habits (P = 0.555). Despite the development of anemia did not differ significantly between the 2 groups (P = 0.957), recovery was significantly higher in patients with ferritin between 30 and 100 μg/L (P = 0.025).Conclusions:
Although IDWA is transient in about one third of patients with CD, another third of the patients will develop anemia during the follow-up. This result highlights the importance of investigation and follow-up of IDWA, particularly in patients with lower values of serum ferritin, in whom recovery is not so frequent.