Iatrogenic Adrenal Insufficiency in a Patient Treated With Telaprevir and Topical Corticosteroids

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Abstract

Telaprevir is a protease inhibitor and known inhibitor of the cytochrome P450 3A4 enzyme. Inhibition of the cytochrome P450 3A4 enzymes can alter levels of medications that are usually targets of its pathway. We present a 56-year-old woman with hepatitis C virus being treated with telaprevir-peginterferon-ribavirin who developed iatrogenic adrenal insufficiency after topical steroid use.

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