Antimicrobial stewardship is an important strategic initiative to ensure patient safety and antimicrobial efficacy. National guidelines advocate the utilization of guidelines and clinical pathways as effective stewardship strategies to enhance the appropriate selection of antimicrobial treatment regimens. This article reviews 3 algorithms using risk stratification techniques implemented within our organization: treatment of acute bacterial skin and skin structure infections, febrile neutropenia, and Clostridium difficile infection. The relevant literature surrounding the utilization of risk stratification tools and applications to other disease states will also be reviewed. Further studies are warranted to evaluate the impact of risk stratification tools on patient outcomes.