Transarterial embolizations have become a common treatment of both unresectable primary and metastatic liver tumors. Infectious complications of this procedure are relatively uncommon because most patients are treated with empiric broad spectrum antibiotics after the procedure. However, infections that may occur include skin infection at the puncture site, hepatic abscess, necrotizing pancreatitis, and cholecystitis. Hepatic abscess formation typically occurs in patients with previous biliary intervention and can often prove fatal. This case describes a patient with no previous biliary intervention who developed Klebsiella pneumoniae hepatic abscess and bacteremia despite prophylactic antibiotics after transarterial bland embolization of a liver metastasis.