Eczema herpeticum in immunocompromised cancer patients if not identified and treated early can be life threatening. It is commonly found in patients with skin integrity disorders, atopic dermatitis, or immunocompromised patients with herpes simplex type 1 infection. The trunk, head, and neck are regions that commonly are involved. Early antiviral therapy is crucial in immunocompromised hosts to prevent a rapid progression of infections. We present a case of adult generalized eczema herpeticum and a review of the differential diagnosis, and management options.