Occult Hepatitis B Virus Reactivation in a Seronegative Stem Cell Transplant Recipient

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Occult Hepatitis B virus infection is not a well-recognized entity. We describe the case of a seronegative (HB surface antigen, HB core antibody, and HB surface antibody negative) patient who had reactivation of occult hepatitis B infection after an allogenic stem cell transplantation. Whether every potential stem cell recipient should be screened for hepatitis B DNA in serum before transplantation is unclear. The case report raises the awareness of possible reactivation of occult hepatitis B infection in completely seronegative transplant recipients who present with elevated serum transaminase levels.

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