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Dapagliflozin is a new oral antidiabetic medication from the sodium glucose cotransporter-2 inhibitor class. Sodium glucose cotransporter-2 inhibitors work by preventing reabsorption of glucose in the kidney, thereby wasting it through urine. This unique mechanism increases the risk of urinary tract infections and genital mycotic infections. We present a rare case of fungal emphysematous pyelonephritis in a patient on dapagliflozin.