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Vertebral bone infections caused by Candida species are uncommon, but their reported frequency is increasing. Candida parapsilosis, a commensal of human skin, is currently an emerging human pathogen, with increasing prevalence and medical significance. We report the case of a Caucasian man who presented with C. parapsilosis spondylodiscitis, who was having a persistent low back pain for 3 months before diagnosis. He had no history of immunosuppression, fever, or elevation of inflammatory markers. The diagnosis was made by fine needle aspiration and culture. A combined medical and surgical intervention was necessary to achieve the best outcome in our case.