Reducing Antimicrobial Toxicity: Time to Move from Mice to Men in a Clinical Trial

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Abstract

SYNOPSIS: Clinically relevant doses of bactericidal antibiotics (quinolones, aminoglycosides and β-lactams) were shown to cause mitochondrial dysfunction and overproduction of reactive oxygen species in mammalian cells in vitro and in mice, leading to oxidative tissue damage. The antioxidant acetylcysteine prevented these effects.

SOURCE: Kalghatgi S, et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Sci Transl Med 2013; 5:192ra85.

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